Formiminoglutamate excretion in rat urine after whole body irradiation, histidine administration, starvation and stress
Hilgertová, J.; Sonka, J.
Physiologia Bohemoslovaca 26(6): 565-572
1977
ISSN/ISBN: 0369-9463 PMID: 147475 Document Number: 116824
Formiminoglutamate (FIGLU) urinary excretion was studied in rats subjected to whole body 60Co irradiation with doses of 450, 650 and 850 R. During the first post-irradiation days, FIGLU excretion doubled after both lower doses. From day 3, 450 R led to a decrease, whereas 650 and 850 R were followed by a still enhanced FIGLU excretion. No correlation to the radiation dose was found. A daily intraperitoneal administration of histidine in a dose of 200 mg/kg led to a constant 5-fold increase of FIGLU output and to more distinct differences in post-irradiation FIGLU excretion. Two days starvation or ACTH administration, followed by doubled urinary total 17-hydroxycorticoids, did not interfere with FIGLU excretion.