A potent antinociceptive cannabinoid which lacks opiate substitution properties in monkeys
Martin, B.R.; Dewey, W.L.; Aceto, M.D.; Adams, M.D.; Earnhardt, J.T.; Carney, J.M.
Research Communications in Chemical Pathology and Pharmacology 16(1): 187-190
1977
ISSN/ISBN: 0034-5164 PMID: 402685 Document Number: 116520
(-)-9-Nor-9beta-hydroxy-hexahydrocannabinol[(-)-9-nor-9beta-OH-HHC] produced hypotension and bradycardia in anesthetized dogs, was a potent antinociceptive agent in the mouse tail-flick and p-phenylquinone abdominal-stretching tests, but did not reverse the effects of morphine withdrawal in dependent monkeys.
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