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Theophylline concentrations in asthmatic patients after administration of aminophylline

Kordash, T.R.; Van Dellen, R.G.; McCall, J.T.

JAMA 238(2): 139-141

1977

ISSN/ISBN: 0098-7484
PMID: 577283
Document Number: 116289
To test the efficacy of using a weight-derived formula to determine aminophylline dosages, 50 patients hospitalized for treatment of severe asthma were given intravenous aminophylline infusions at a rate of 0.9 mg/kg/hr to a maximum dosage of 1,500 mg/24 hr. Serum theophylline determinations done 12 to 96 hours after institution of this therapy showed levels greater than 20 mg/liter in 34% of these patients. Reliance on weight-derived formulas can be dangerous.

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