Effect of 1,1-dichloroethylene exposure on hepatic mitochondria
Jaeger, R.J.
Research Communications in Chemical Pathology and Pharmacology 18(1): 83-94
1977
ISSN/ISBN: 0034-5164 PMID: 905636 Document Number: 116181
Inhalation exposure of 18 h fasted male rats to 1,1-dichloroethylene cycle. These results suggest mitochondrial injury as a result of 1,1-DCE exposure. The elevation of citric acid concentration suggests that monochloroacetic acid, a known metabolite of 1,1-DCE, may be converted to monochlorocitric acid, an inhibitor of aconitase in the TCA cycle. The monochloroacetic acid may be toxic to mitochondria by a direct action.
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