On the interaction between the anti-inflammatory substance proquazone (RU 43-715) and phenprocoumone
Vinazzer, H.
International Journal of Clinical Pharmacology and Biopharmacy 15(5): 214-216
1977
ISSN/ISBN: 0340-0026 PMID: 326688 Document Number: 116118
In a double blind study on 20 anticoagulated patients, the influence of the anti-inflammatory drug 1-isopropyl-4-phenyl-7-methyl-2 (1H) quinazolone on the degree of hypocoagulability was examined. In comparison to a placebo group, there was no statistical difference in the Quick precentage, in coagulation factors II, VII, and X, and in platelet aggregation induced by collagen and by epinephrine respectively. In addition, no increased bleeding tendency could be observed during the study.