Migration and differentiation of hematopoietic stem cells depending on the level of endogenous corticoids in the body
Bezin, G.I.; Moroz, B.B.; Petrov, R.V.; Khaitov, R.M.; Romashko, O.O.
Problemy Gematologii i Perelivaniia Krovi 22(12): 21-27
1977
ISSN/ISBN: 0552-2080 PMID: 202943 Document Number: 116114
Significant inhibition of mouse stem cell migration from the bone marrow area, screened during irradiation, occurred with a hypercorticoid condition produced by prolonged action of ACTH injected in various doses. In considerable suppression of stem cell migration, a reduction of erythropoietic potency of the colony-forming units was noted with a relative increase of their capacity for differentiation in the direction of granulopoiesis. The level of the colony-forming cells circulating in the blood decreased sharply with high endogenous glucocorticoid concentrations in the blood plasma of nonirradiated mice.