Factors influencing plasma carbamazepine concentrations
Lander, C.M.; Eadie, M.J.; Tyrer, J.H.
Clinical and Experimental Neurology 14: 184-193
1977
ISSN/ISBN: 0196-6383 PMID: 616596 Document Number: 115914
Steady-state plasma carbamazepine levels were correlated with carbamazepine dose, expressed on a body weight basis, in 217 patients (some of whom were taking other anticonvulsants). Although there was a linear relation between plasma carbamazepine level and drug dose in the whole population studied, no such relation was found for patients taking carbamazepine alone. The factors responsible for this difference could not be identified in full, but interactions between carbamazepine and phenytoin were partly responsible.
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