Half life of injected 125I-insulin in control and ob/ob mice
Cresto, J.C.; Lavine, R.L.; Buchly, M.L.; Penhos, J.C.; Bhathena, S.J.; Recant, L.
Acta Physiologica Latino Americana 27(1): 7-15
1977
ISSN/ISBN: 0001-6764 PMID: 616173 Document Number: 115046
The t-1/2 of moniodo 125I-insulin in ob/ob mice and their lean litter mates is 10 min. No difference was found between the two groups. Further, 48 hr of fasting did not alter the t-1/2 in ob/ob mice. In view of the markedly enlarged insulin pool in ob/ob mice, one must conclude that the mass of insulin degraded in unit time is increased. However, these findings indicate that the cause of hyperinsulinism in ob/ob mice is unrelated to rates of insulin degradation.