Circannual Temperature-Related Variation in Hemoglobin A1c is Unlikely to Affect its use as a Diagnostic Test for Type 2 Diabetes
Xue, L.; Liang, H.; Jiang, X.
Clinical Laboratory 58(5-6): 481-488
2012
ISSN/ISBN: 1433-6510 PMID: 22783578 Document Number: 11431
Background: To evaluate the relationship between temperature and hemoglobin A 1c (HbA 1c ) and fasting plasma glucose (FPG) levels in Harbin of China and analyze whether these would affect diagnosis and control of diabetes. Methods: Two groups were investigated: 1. Routine patients come from outpatients, 2. Research subjects including 224 healthy volunteers and 391 diabetic patients, who had 5 blood specimens collected between February and June 2010. Fasting plasma glucose and hemoglobin A 1c were detected. Results: In non-diabetic patients, mean HbA 1c concentrations for all temperature categories were not significantly different, but mean FPG level was higher at cooler temperatures (p 1c concentrations were higher at cool temperatures than at very cold temperatures (p 1c were smaller than for FPG. Conclusions: During the year of this study, there were substantial temperature fluctuations but HbA 1c concentration was more stable than FPG in non-diabetic individuals. It is therefore unlikely that temperature-related variation in HbA 1c could affect the use of HbA 1c as a diagnostic test for type 2 diabetes, but could affect the use of HbA 1c as a glycemia control test for diabetes.
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