Effect of mianserine on brain serotonin turnover in mice
Bhargava, H.N.; Kasabdji, D.
Research Communications in Chemical Pathology and Pharmacology 17(4): 735-738
1977
ISSN/ISBN: 0034-5164 PMID: 897355 Document Number: 114104
One hour after mianserine administration, brain 5-HT [5-hydroxytryptamine] concentration was reduced; the greatest decrease was observed with 2.5 mg/kg dose. This reduction lasted for 1 h. Brain 5-HT turnover was increased by all mianserine doses used. The increase in brain 5-HT turnover after a single injection lasted for 8 h. This increase may be related to central 5-HT receptor inhibition.
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