Chemotherapy-associated tongue hyperpigmentation and blue lunula
Casamiquela, K.M.; Cohen, P.R.
Journal of Drugs in Dermatology Jdd 12(2): 223-226
2013
ISSN/ISBN: 1545-9616 PMID: 23377398 Document Number: 11401
Combination chemotherapy is associated with cutaneous and mucosal side effects. Antineoplastic agents have been associated with mucosal and nail pigmentation. We describe a 16-year-old Saudi Arabian girl with combination chemotherapy-associated black tongue hyperpigmentation and blue lunula. The diagnosis of drug-associated pigmentary changes is based on correlating the onset of the clinical observations with the temporal initiation of the patient's chemotherapy agents. Spontaneous fading of antineoplastic therapy-induced tongue or nail dyschromia may subsequently occur following discontinuation of the causative drug.
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