Metal carcinogenesis: a study of the carcinogenic activity of solid metal alloys in rats
Gaechter, A.; Alroy, J.; Andersson, G.B.; Galante, J.; Rostoker, W.; Schajowicz, F.
Journal of Bone and Joint Surgery. American Volume 59(5): 622-624
1977
ISSN/ISBN: 0021-9355 PMID: 873958 Document Number: 112901
The carcinogenic activity of seven metallic alloys was studied by implanting solid rods of each alloy in the gluteal muscles of Sprague-Dawley rats which were killed after twenty-four months. When the number of tumors in these rats was compared with the numbers in rats not operated on, in rats which had a sham operation, and in rats implanted with Silastic rods, no statistically significant differences in the incidences of the tumors in the several groups were found.