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Activation of the classical and properdin pathways of complement by bacterial lipopolysaccharides (LPS)

Morrison, D.C.; Kline, L.F.

Journal of Immunology 118(1): 362-368

1977

ISSN/ISBN: 0022-1767
PMID: 318670
Document Number: 112775
LPS lipid A region of the LPS is responsible for classical pathway activation and the polysaccharide region responsible for properdin pathway activation. Classical pathway activation by lipid A does not depend upon antibody to the lipid A and properdin pathway activation proceeds by a lipid A-independent mechanism. The polysaccharide portion of the LPS molecule exerts a modifying influence on the potential anticomplementary activity of the lipid A.

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