Bone remodeling in chronic renal failure in perinatally irradiated beagles
Villafañe, F.; Norrdin, R.W.; Lopresti, C.A.; Kimmel, D.
Calcified Tissue Research 23(2): 171-178
1977
ISSN/ISBN: 0008-0594 PMID: 407990 Document Number: 112567
Tetracycline-based bone remodeling was studied in multiple rib samples from 12 control beagles and from 27 perinatally irradiated beagles with different stages of renal disease, when biopsied or sacrificed at 2 and 4 yr of age. In haversian bone, the 10 dogs with marked uremia showed, as a group, a trend (P < 0.10) toward slightly higher cell level bone formation. Tissue-level bone formation was increased (P < 0.01) due to an increased number (P < 0.01) of filling osteons associated with an increased number (P < 0.01) of new remodeling units. An increase in the number of resorption cavities (P < 0.01) also contributed to an increase in the intracortical porosity (P < 0.01). An estimation of resorption rate at the cellular level was no different in the markedly uremic dogs, but was increased (P < 0.01) at the tissue level. On the periosteal and cortical-endosteal surfaces, the increased number of resorption sites (P < 0.01) was not balanced by formation activity as measured by tetracycline-labeled surface. This imbalance may be responsible for a decrease (P < 0.05) in cortical cross-section area. Parathyroid hyperplasia present in these markedly uremic dogs was considered the principal etiologic factor. Eleven dogs with mild renal disease had similar trends in remodeling parameters, but they differed significantly from the nonuremic groups only in the number of periosteal resorption sites.