E-rosette forming lymphocytes in acute leukemia before and after cell incubation with human serum thymic factor
Ozger Topuz, U.; Okçuoglu Cavdar, A.; Astaldi, G.
Bollettino dell'Istituto Sieroterapico Milanese 56(5): 449-456
1977
ISSN/ISBN: 0021-2547 PMID: 304352 Document Number: 111900
The Authors studied the effect of the human serum thymic factor on the peripheral blood leukocytes from ALL patients, by testing the frequency of the E+ cells by means of the E rosette assay before and after cell incubation with this factor. In four out of twenty-four patients tested, the thymic factor incubation of peripheral blood mononuclears increased the number of E+ cells. The shift from E- to E+ cells caused by the human serum thymic factor occurred among null cells (E-, SM-Ig-). The possible value of the test in investigating whether a T0 leukemia might really exists is pointed out, as well as its prospective importance in monitoring the variations of the immature T cell counts in relationship to the patient's treatment and his disease course.