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Introduction of artificial crosslinks into proteins

Uy, R.; Wold, F.

Advances in Experimental Medicine and Biology 86a: 169-186

1977

ISSN/ISBN: 0065-2598
PMID: 21534
Document Number: 111764
In this chapter, we present a brief overview of the current status of protein crosslinking technology. An attempt is made to compare the natural crosslinks and natural crosslinking agents to the artificial ones, and a brief section is devoted to the potential use of enzymes (transglutaminase and peroxidase) as crosslinking agents in vitro. Homobifunctional (x-R-x) and heterobifunctional (x-R-y) reagents are considered in terms of the kinds of functional groups and R-groups that have been used in protein crosslinking, and some examples of reagents and applications from the recent literature are tabulated.

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