Association of Lipid and Inflammatory Markers with C-Reactive Protein in Cardiovascular Risk Assessment for Primary Prevention
Snežana Jovičić; Ignjatovi, S.ć; Dajak, M.; Kangrga, R.; Majki, N.ć-Singh
Clinical Laboratory 55(11-12): 411-419
2009
ISSN/ISBN: 1433-6510 PMID: 20225663 Document Number: 11090
Background: High-sensitivity C-reactive protein (hsCRP) has been recognized as an independent marker of cardiovascular risk. Since atherosclerosis is a multifactorial disease, the aim of this study was to determine association between hsCRP and other markers of inflammation and dyslipidemia. Materials and Methods: In 242 healthy volunteers, total cholesterol (TC), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), nonHDL-C, triglycerides (TG) and hsCRP were measured using Olympus AU2700. Apolipoprotein A-I (apoAI), apolipoprotein B (apo B), lipoprotein (a) (Lp(a)), haptoglobin, α1-acid glycoprotein (A1AGP), C3 and C4 complement components were determined on Architect c8000, and serum amyloid A (SAA) and fibrinogen on BN II nephelometer and ACL 7000, respectively. Results: Significant (P Conclusion: The prediction of risk for future cardiac events based on hsCRP concentration, which is the recom- mended parameter for improving cardiovascular risk stratification, might be complemented with the information about BMI, nonHDL-C, fibrinogen and SAA.
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