Association of -592 Region of IL-10 Polymorphisms with Asthma in South-Eastern Iranian Patients
Hakimizadeh, E.; Arababadi, M.K.; Hassanshahi, G.; Ahmadabadi, B.N.; Hakimi, H.; Rezaeian, M.; Salehabadi, V.A.; Yousefidaredor, H.; Abousaidi, H.; Kennedy, D.
Clinical Laboratory 58(3-4): 267-271
2012
ISSN/ISBN: 1433-6510 PMID: 22582500 Document Number: 11081
Background: Cytokines are considered important factors for the pathogenesis of asthma as they play a key role in the regulation of immune responses. The aim of this study was to investigate the association between this disease and polymorphisms in the -592 region of the IL-10 gene. Methods: This study was carried out on 100 asthmatic patients and 100 healthy controls. PCR-RFLP was applied to examine the polymorphisms in the -592 region of the IL-10 gene. Results: Our results showed a significant difference between patients and controls in terms of genotypes and alleles of the -592 region of the IL-10 gene. Conclusions: According to our results, it can be concluded that the IL-10 promoter polymorphisms may play a crucial role in the pathogenesis of asthma.
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