Characteristics of the interaction of 9,10-dimethyl-1,2-benzanthracene with the hairy cells in the central nervous system
Mardanova, G.V.
Biulleten' Eksperimental'noi Biologii i Meditsiny 84(8): 197-199
1977
ISSN/ISBN: 0365-9615 PMID: 409443 Document Number: 110694
The implantation of a pill containing carcinogen DMBA into the right hemisphere of the rat brain induces the formation of a capsule, the innermost layer of which is composed of "hairy" cells. Two principally different mechanisms of carcinogen penetration into the "hairy" cell were distinguished: ordinary phagocytosis and biochemical interaction of carcinogen with the cell membrane. It is supposed that in the second case there occurs formation of secondary carcinogenic products in the form of steroid hormone which could be morphologically identified as lipid-like structures of the "hairy" cell.