The role of inflammatory cells in the pathogenesis of amyloidosis
Kisilevsky, R.; Axelrad, M.; Corbett, W.; Brunet, S.; Scott, F.
Laboratory Investigation; A Journal of Technical Methods and Pathology 37(6): 544-553
1977
ISSN/ISBN: 0023-6837 PMID: 599900 Document Number: 110644
In the presence of amyloid enhancing factor, a variety of inflammatory stimuli, many of them nonantigenic, trigger amyloid deposition in 48 h . There is a striking correlation between the extent of splenic amyloid deposition and the severity of inflammation at the injection site of the various irritants. Sublethal irradiation results in a parallel effect on the local inflammatory response and the accompanying extent of amyloid deposition produced in the spleen. Evidence that a product of local acute inflammatory responses is related to the deposition of amyloid is also presented. It is proposed that this product is a protease derived from the infiltrating polymorphonuclear leukocytes.