Biochemical interaction between anorectic drugs and piribedil
Jori, A.; Dolfini, E.
Journal of Pharmacy and Pharmacology 29(9): 581-582
1977
ISSN/ISBN: 0022-3573 PMID: 21274 Document Number: 110634
Rats were injected i.p. with the following anorectic drugs: (+)-amphetamine sulfate, (-)-fenfluramine hydrochloride, methylamphetamine hydrochloride, S992 (trifluoro-methylphenyl(benzoyloxy)ethyl-amino-2-propane), SKF1-39728 (1-N-benzyl-methoxy-3-trifluoromethylphenethylamine), mazindol (5-(p-chlorophenyl)-2-5-dihydro-3H-imidazo concentrations from 50 and 180% compared with control animals. When piribedil was given before the drugs, the effect of fenfluramine, S992 and SKF1-39728 was strongly counteracted. Pretreatment with piribedil did not inhibit amphetamine (significant interaction), methylamphetamine or maxindol (for these 2 drugs the interaction was not significant because of data variability). The effect of diethylpropion was reduced but not blocked by piribedil. Similar results were obtained when double the doses of piribedil or diethylpropion were used. HVA concentrations after these combined treatments were always lower than after diethylpropion alone, the quantitative difference being about the same as the decrease caused by piribedil alone.