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Analysis of KIR genes in HLA-identical sibling hematopoietic stem cell transplantation in Thai patients with leukemia

Wongwuttisaroj, N.; Vejbaesya, S.; Chongkolwatana, V.; Issaragrisil, S.

Journal of the Medical Association of Thailand 95(10): 1261-1265

2012

ISSN/ISBN: 0125-2208
PMID: 23193738
Document Number: 10931
Killer cell immunoglobulin-like receptors (KIRs) are members of a group of regulatory molecules found on the natural killer (NK) cells that regulate NK cells function by interacting with the human leukocyte antigen (HLA) class I molecules or ligands. The effects of KIR genes on the outcome of hematopoietic stem cell transplantation (HSCT) are still controversial. To investigate the distribution of KIR genes in HLA-identical sibling and the effect of KIR genes on the outcome of HSCT. The present study included 74 patients and their HLA-identical sibling donors. KIR genes and HLA ligands typing were determined by polymerase chain reaction-sequence specific primer (PCR-SSP). A retrospective study was carried out to analyze the outcomes of the recipients. There was no effect of KIR gene mismatch and missing ligand on the outcome regarding graft-versus host disease (GVHD), relapse, and overall survival (OS) (p > 0.05). However the presence of donor activating KIR2DS5 was associated with decreased aGVHD (p = 0.01). Our findings suggest an important role of donor activating KIR in identical sibling HSCT.

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Analysis of KIR genes in HLA-identical sibling hematopoietic stem cell transplantation in Thai patients with leukemia

Ngamkiatphaisan, S.; Sriratanaban, J.; Kamolratanakul, P.; Intragumtornchai, T.; Noppakun, N.; Jongudomsuk, P. 2007: Cost analysis of hematopoietic stem cell transplantation in adult patients with acute myeloid leukemia at King Chulalongkorn Memorial Hospital Journal of the Medical Association of Thailand 90(12): 2565-2573
Yu, Z.-p.; Ding, J.-h.; Chen, B.-a.; Wu, F.; Gao, C.; Sun, Y.-y.; Chen, J.; Zhao, G.; Wang, J.; Li, Y.-f.; Ding, B.-h.; Qian, J. 2011: Analysis of risk factors for relapse of 82 patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation Zhonghua Zhong Liu Za Zhi 33(4): 283-286
de Witte, T.; Brand, R.; van Biezen, A.; Delforge, M.; Biersack, H.; Or, R.; Meloni, G.; Bandini, B.; Sierra, J.; Kroger, N.; Gratwohl, A.; Niederwieser, D. 2006: The role of stem cell source in autologous hematopoietic stem cell transplantation for patients with myelodysplastic syndromes Haematologica 91(6): 750-756
Kanda, Y. 2012: Chemotherapy and hematopoietic stem cell transplantation for acute lymphoblastic leukemia Nihon Rinsho. Japanese Journal of Clinical Medicine 70(Suppl 2): 447-455
Basak, G.; Torosian, T.; Snarski, E.; Niesiobedzka, J.; Majewski, M.; Gronkowska, A.; Urbanowska, E.; Jedrzejczak, W. 2010: Hematopoietic stem cell transplantation for T315I-mutated chronic myelogenous leukemia Annals of Transplantation 15(2): 68-70
Yano, S. 2011: The role of allogenic hematopoietic stem cell transplantation for chronic myeloid leukemia in imatinib era Gan to Kagaku Ryoho. Cancer and ChemoTherapy 38(5): 759-764
McClanahan, F.; Gribben, J. 2015: New insights into hematopoietic stem cell transplantation for chronic lymphocytic leukemia: a 2015 perspective Clinical Advances in Hematology and Oncology: H&o 13(9): 586-594
Styczynski, J.; Toporski, J.; Wysocki, M.; Debski, R.; Chybicka, A.; Boruczkowski, D.; Wachowiak, J.; Wojcik, B.; Kowalczyk, J.; Gil, L.; Balwierz, W.; Matysiak, M.; Krawczuk-Rybak, M.; Balcerska, A.; Sonta-Jakimczyk, D. 2007: Fludarabine, treosulfan and etoposide sensitivity and the outcome of hematopoietic stem cell transplantation in childhood acute myeloid leukemia Anticancer Research 27(3b): 1547-1551
Liu, H.C.; Yao, S.Q.; Peng, J.Y. 1993: A clinical study of autologous hematopoietic stem cells transplantation in 41 patients with leukemia and other malignant diseases Zhonghua Nei Ke Za Zhi 32(7): 461-463
Reiffers, J.; Goldman, J.; Meloni, G.; Cahn, J.Y.; Gratwohl, A. 1994: Autologous stem cell transplantation in chronic myelogenous leukemia: a retrospective analysis of the European Group for Bone Marrow Transplantation. Chronic Leukemia Working Party of the EBMT Bone Marrow Transplantation 14(3): 407-410
Fu, Y.-w.; Zhu, P.; Zhao, X.-w.; Li, H.-f.; Zeng, Z.-z.; Zhang, R.; Wang, Y.-j.; Zhang, Y.; Liu, J.-h. 2003: The variation of T-cell clonal repertoire in patients with systemic lupus erythematosus (SLE) following autologous peripheral blood hematopoietic stem cell transplantation Zhonghua Yi Xue Za Zhi 83(19): 1648-1652
Siena, S.; Bregni, M.; Di Nicola, M.; Magni, M.; Ravagnani, F.; Gandola, L.; Lombardi, F.; Gianni, A.M. 1996: Long-term hematopoietic reconstitution after myeloablative antitumor therapy and circulating hematopoietic stem cell transplantation Tumori 82(2 Suppl): S23-S27
Numbenjapon, T.; Nademanee, A. 2008: Hematopoietic stem cell transplantation for patients with advanced-stage follicular lymphoma Journal of the Medical Association of Thailand 91(10): 1613-1622
Wang, J.-z.; Liu, D.-h.; Xu, L.-p.; Chen, H.; Liu, K.-y.; Huang, X.-j. 2007: Itraconazole for treatment of fungal infections in patients undergoing allogeneic hematopoietic stem cell transplantation Zhonghua Nei Ke Za Zhi 46(1): 29-31
Chen, Y.; Xu, L-ping.; Liu, D-hong.; Chen, Y-hong.; Han, W.; Shi, H-xia.; Zhang, X-hui.; Wang, J-zhi.; Chen, H.; Liu, K-yan.; Huang, X-jun.; Lu, D-pei. 2007: Donor peripheral stem cells infusion for the treatment of failure of platelet recovery after allogeneic hematopoietic stem cell transplantation Zhonghua Yi Xue Za Zhi 87(14): 964-966
Tang, F.F.; Zhang, X.H.; Chen, H.; Chen, Y.Y.; Han, W.; Wang, J.Z.; Wang, F.R.; Chen, Y.; Huang, X.J.; Xu, L.P. 2017: Surgical treatment of severe, refractory hemorrhagic cystitis following allogeneic hematopoietic stem cell transplantation: a report of 17 patients Zhonghua Nei Ke Za Zhi 56(6): 414-418
Atkinson, K.; Downs, K.; Ashby, M.; Dodds, A.; Concannon, A.; Biggs, J. 1989: Recipients of HLA-identical sibling marrow transplants with severe aplastic anemia engraft more quickly, and those with chronic myeloid leukemia more slowly, than those with acute leukemia Bone Marrow Transplantation 4(1): 23-27
Annibali, R.; Caponi, L.; Morganti, A.; Manna, M.; Gabrielli, O.; Ficcadenti, A. 2013: Hunter syndrome (Mucopolysaccharidosis type II), severe phenotype: long term follow-up on patients undergone to hematopoietic stem cell transplantation Minerva Pediatrica 65(5): 487-496
Yamane, A.; Okamoto, S. 2012: Hematopoietic stem cell transplantation Nihon Rinsho. Japanese Journal of Clinical Medicine 70(Suppl 2): 226-229
Harada, M. 2007: Hematopoietic stem cell transplantation Nihon Rinsho. Japanese Journal of Clinical Medicine 65(Suppl 1): 585-589