Serum gastrin levels in patients with renal failure on maintenance haemodialysis and after successful kidney transplantation
Muolo, A.; Ghidini, O.; Tonon, M.; Galvani, E.; Baratta, P.F.; Confortini, P.
La Ricerca in Clinica e in Laboratorio 6(3): 277-284
1976
ISSN/ISBN: 0390-5748 PMID: 799830 Document Number: 109301
Chronic renal failure in man is associated with a hypergastrinemia which is not corrected by hemodialysis. Serum gastrin concentrations were measured in 66 patients on maintenance hemodialysis and in 27 patients after successful kidney transplantation. The basal gastrin levels distinguished 2 groups of patients on maintenance hemodialysis: a 1st group with gastrin values .ltoreq. 120 pg/ml (mean 58 .+-. 29.88 pg/ml) and a 2nd group with gastrin values > 120 pg/ml (mean 295 .+-. 257 pg/ml). The onset of urine output after kidney transplantation was associated with a dramatic fall in gastrin concentration (3 patients studied in the early post-transplant period). Patients (24) with stabilized transplant function had serum gastrin levels < 120 pg/ml (mean 21.33 .+-. 17.29 pg/ml). The gastrin response to a standard protein meal depended on the basal gastrin concentration and was different in patients with renal failure on maintenance hemodialysis and those with a successful kidney transplantation.