Differential inhibition of embryonic cell aggregation by cultured human cells with "malignant" of "normal" characteristics
Maslow, D.E.; Mayhew, E.; Minowada, J.
Cancer Research 36(8): 2707-2709
1976
ISSN/ISBN: 0008-5472 PMID: 1277179 Document Number: 109273
The effect that cultured human cells have on chick embryonic neural retina cell aggregation was examined. Different types of human cultured cells inhibited aggregation of chick neural retinal cells to different degrees when mixed at a human cell:retina cell ratio of 1:60. It appeared from the 11 cell lines studied that cells with malignant characteristics inhibited retinal cell aggregation to a greater extent than those with more normal characteristics. The assay could be used as a further test for abnormality of cell types and also as a method for studying the interactions of malignant cells with cultured cells.