An evaluation of a once daily dosage régime of dothiepin hydrochloride (prothiaden)
Rees, J.A.; Risdall, P.C.
Journal of International Medical Research 4(5): 319-325
1976
ISSN/ISBN: 0300-0605 PMID: 1028633 Document Number: 108730
The use of a single daily oral dose of dothiepin hydrochloride (Prothiaden) was reported. The results from a metabolism study using [14C] dothiepin were used to calculate the daily variations in blood levels after once daily and thrice daily dose regimes. A clinical study on the use of a single daily dose of 75 mg of dothiepin showed this type of regime to be well tolerated and efficacious in the treatment of 105 depressed patients in general practice. Compared to a thrice daily regime the once daily dose appeared to be more beneficial on symptomatic insomnia during the early treatment period.