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Stimulation by hydrocortisone of the rate of collagen synthesis in cultured fibroblasts

Doherty, N.S.; Saarni, H.

Journal of Pharmacy and Pharmacology 28(8): 656-657

1976

ISSN/ISBN: 0022-3573
PMID: 11322
Document Number: 108674
A water soluble anti-inflammatory steroid, hydrocortisone sodium succinate was used on human fetal fibroblasts. Hydrocortisone sodium succinate at concentrations between 10-7 M and 10-4 M did not inhibit either collagen or non-collagen protein synthesis, when the total incubation period was 5 h. At 10-5 M a statistically significant stimulation of collagen synthesis was found (133% of control, P < 0.02, n = degrees of freedom = 10) was found. There was also a slight non-significant (107% of control) stimulation of noncollagen protein synthesis.

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