Phentermine (Duromine) for obese diabetics
Jackson, W.P.; Vinik, A.I.
South African Medical Journal 50(35): 1351
1976
ISSN/ISBN: 0256-9574 PMID: 968682 Document Number: 108203
The appetite suppressant phentermine is a much weaker stimulant of the central nervous system than its parent substance, amphetamine. In a trial at Cape Town, 36 obese diabetics, all having failed to lose weight satisfactorily and all but 2 of maturity-onset type, continued on their usual treatment and diet, attended clinic monthly, and after 1 month of attendance got either phentermine or a placebo, one tablet daily, the treatment alternating monthly. Ten did not complete the trial, but not because of side effects; there was no side effect. The other 26 lost a total of 634 kg while taking phentermine and gained 21 kg while taking placebo. Mean weight loss on phentermine was 0.81 kg/month; 23 persons lost weight and 3 gained weight on phentermine while 8 lost and 18 gained on placebo. Phentermine capsule, 30 mg, daily induced significant weight loss in resistant obese diabetics in the short term without serious side effect.