Influence of L-leucine overloading on the level of free amino acids in the diabetic rat
Grizard, J.; Maciejewska, M.; Prugnaud, J.; Pion, R.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 170(1): 103-111
1976
ISSN/ISBN: 0037-9026 PMID: 134759 Document Number: 107886
Alloxan injection in the rat results in a large increase of branched free amino acids (leucine, isoleucine, valine) in the blood, liver and muscle; it decreases most of the non essential free amino acids in liver. L-leucine administration in the diabetic rat results in a large decrease of plasma corticosterone. It increases free leucine but decreases free isoleucine and valine in blood and muscle. It decreases most of the essential free amino acids in liver.