Activity of sympathetic nerves in heart during cardiopulmonary bypass in patients
Barta, E.; Kuzela, L.; Kvetnansky, R.; Siska, K.; Babusikova, F.; Torda, M.; Cornak, V.; Horecky, J.
Journal of Cardiovascular Surgery 17(2): 174-177
1976
ISSN/ISBN: 0021-9509 PMID: 1262388 Document Number: 107711
The sympathetic nerve activity in heart during cardiopulmonary bypass was studied in 20 patients. The rate of release of dopamine-beta-hydroxylase from cardiac nerves was used as an indicator. It was found that the thoracotomy alone does not represent such a stimulus which would lead unambiguously to sympathetic overactivity in heart. Cardiopulmonary bypass represents, on the other hand, an intensive sympathomimetic stimulus, as it was demonstrated by significnat increase of coronary A-V difference negativity of dopamine-beta-hydroxylase as early in 15th minute of its duration. The washout of enzyme to the end of 30 min. duration of bypass still increased. After finishing of bypass the coronary A-V diff. of dopamine-beta-hydroxylase again decreased.