Lincomycin formation by strain R-367 on a complex medium not containing corn steep
Kochetkova, G.V.; Nechaeva, N.P.; Ukholina, R.S.
Antibiotiki 21(2): 99-102
1976
ISSN/ISBN: 0003-5637 PMID: 945038 Document Number: 107352
A new complex medium for biosynthesis of lincomycin by strain R-367 was developed using one-factor experiments and mathematical schemes of planning. A complex of mineral salts containing nitrogen, sulphur, phosphurus, magnesium and trace elements was introduced into the content of the new medium. This provided elimination of corn steep liquor from the medium. The linomycin production level in the fermentation broth with the use of the new medium was at an average 2.5 times higher than that on the initial medium containing corn steep liquor.