External respiration and the functional state of the respiratory center in hypoxia developing against a background of inactivated carbonic anhydrase
Kulik, A.M.; Kondrat'eva, L.N.; Tarakanov, I.A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 81(2): 152-156
1976
ISSN/ISBN: 0365-9615 PMID: 1276403 Document Number: 106385
Experiments were conducted on cats; inactivation of carboanhydrase with diamox prevented developmento f hypocapnia and disturbances of the rhythmic activity of the respiratory neurons associated with it in acute hypoxia. However, comparision of electrophysiological data, external respiration indices, of the acid-base balance, pO2 and pCO2 of arterial blood demonstrated that, preventing development of pathological Cheyne-Stokes respiration under conditions of hypoxia, inactivation of carboanhydrase with diamox caused dissociation of the thoracic and abdominal respiration and dyspnea. The latter led to shifts in the metabolic processes and to disturbance of the electrolyte metabolism at the cell level.