A multiple-domain framework of clinical, economic, and patient-reported outcomes for evaluating benefits of intervention in atopic dermatitis
Boguniewicz, M.; Abramovits, W.; Paller, A.; Whitaker-Worth, D.L.; Prendergast, M.; Cheng, J.Wang.; Wang, P.; Tong, K.B.
Journal of Drugs in Dermatology Jdd 6(4): 416-423
2007
ISSN/ISBN: 1545-9616 PMID: 17668539 Document Number: 10545
Atopic dermatitis (AD) increases health care utilization, affects patient quality of life, places a burden on caregivers, decreases patient/parent productivity, and adds to health care costs. Few studies have examined the effect of specific treatment modalities across a variety of AD-related outcomes. This prospective, multicenter, open-label longitudinal study of adult and pediatric patients with moderate to severe AD was conducted to evaluate the effect of a specific therapeutic intervention on AD-related outcomes over a period of 6 months. Surveys collected physician clinical assessments and patient- and caregiver-reported data across the following domains: clinical outcome, health care utilization/costs, quality of life, physical appearance, productivity/absenteeism, and medication compliance. This study is intended to help guide future research efforts on the net costs and benefits of different interventions across a diverse set of domains and in larger populations.
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