A First Report on Hb Q-Iran in Association with Alpha-thalassemia in a Case of Spinal Ischemia
Zur, B.; Hildesheim, A.; Ludwig, M.; Stoffel, B.-Wagner
Clinical Laboratory 57(3-4): 221-224
2011
ISSN/ISBN: 1433-6510 PMID: 21500730 Document Number: 10523
Background: Hemoglobin Q-Iran is a rare variant which has not been described in association with alpha-thalas-semia to date. We present the case of a Turkish patient who developed spinal ischemia. Methods: Spinal ischemia was diagnosed clinically, via magnetic resonance imaging and angiographically. Blood samples were analyzed by high performance liquid chromatography, electrophoresis, gene sequencing, hematological and biochemical analysis. Results: We detected hemoglobin Q-Iran in association with alpha-thalassemia. The same hemoglobinopathy was detected in two members of the patient's family. Conclusions: As various differential diagnosis approaches failed to reveal the cause of spinal ischemia, the combined hemoglobinopathy was eventually postulated.
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