Learning and chronobiological regulation following experimental damage to the coronary-artery wall of albino rats
Hecht, K.; Choinowski, S.; Kunde, D.; Meyer, R.; Moritz, V.; Schlegel, T.; Wenzelides, K.; Götze, J.
Acta Biologica et Medica Germanica 35(5): 559-570
1976
ISSN/ISBN: 0001-5318 PMID: 983607 Document Number: 105141
Forty male albino rats were used to study the relationship between experimentally (concentrated hydrochloric acid) produced local structural changes of the coronary artery wall and central nervous information processing and chronobiological events, respectively. The alterations of the coronary arteries caused by this treatment did not produce infarction but initiated on the whole length of the arterial branch proliferative processes that are complete within 12 weeks following the intervention. Central nervous information processing and chronoregulatory processes showed, immediately after exposure to hydrochloric acid, pronounced malfunctions followed by a stage of hyperreactivity (4 weeks following the damage). At 8 weeks from the intervention, the parameters of information processing and chronobiological events of the CNS again equalled the control values. Since the central nervous functions were back to normal earlier than the structural alterations, the results are interpreted as reflecting CNS-controlled interactions between the complex of visceral afference and efference, the regulation of which is determined by the CNS after coronary damage in such a way as to restore the adaptational capacity of the organism by a predominance of sanogenetic processes.