Regional brain catecholamine levels after intraventricular 6-hydroxydopamine in the neonatal rat
Pappas, B.A.; Saari, M.; Peters, A.V.
Research Communications in Chemical Pathology and Pharmacology 14(4): 751-754
1976
ISSN/ISBN: 0034-5164 PMID: 959671 Document Number: 104998
The neurochemical effects of neonatal intracerebral and peripheral injections of 6-hydroxydopamine (6-OHDA) may differ substantially. Intraventricular injections totalling 200 .mu.g of the drug at various ages in the neonate severely depleted forebrain and diencephalic norepinephrine and striatal dopamine but increased pontine norepinephrine. There were differences and similarities between the effects of intraventricular and the reported effects of peripheral 6-OHDA in the neonatal rat.