Relationship between oestrogen, prostaglandin F2alpha and histamine in delayed implantation in the mouse
Saksena, S.K.; Lau, I.F.; Chang, M.C.
Acta Endocrinologica 81(4): 801-807
1976
ISSN/ISBN: 0001-5598 PMID: 946569 Document Number: 104432
Treatment of pregnant mice ovariectomized on day 3 (23.00-2330 h) with progesterone (1 mg/day per mouse, from day 4 through 11 post coitum (p.c.)) and estrogen (single injection of 0.05 .mu.g on day 8 p.c ) induced implantation in all the animals. Implantation was inhibited in animals following 3 s.c. injections of indomethacin given on the morning and afternoon of day 8 and the morning of day 9 p.c. A single injection of histamine on day 8 p.c. partially compensated the effect of indomethacin. A complete reversal of the antifertility effect of indomethacin was achieved following i.p. administration of histamine (2 .mu.g at noon of day 8 p.c.) and PGF2.alpha. [prostaglandin F2.alpha. (20 .mu.g on the morning and afternoon of day 8 p.c.). In the mouse uterus indomethacin probably impairs the physiological changes required for the decidual cell formation and implantation. Probably an injection of estradiol in the progesterone treated ovariectomized mice triggers the release of PGF2.alpha. and histamine, and these compounds may be involved in the chain of events leading to implantation of the blastocysts.