Mechanism of acti on of chronically administered cannabis extract on the female genital tract of gerbils Meriones hurrianae
Dixit, V.P.; Arya, M.; Lohiya, N.K.
Indian Journal of Physiology and Pharmacology 20(1): 38-41
1976
ISSN/ISBN: 0019-5499 PMID: 1270123 Document Number: 104290
Daily administration of cannabis extract (2.5 mg/day for a period of 60 days) caused degenerative changes in the ovarian tissue. Luteinization was inhibited. Corpus-luteum degeneration was conspicuous. Distinct effects were produced upon the uterine biochemistry, consisting of decreased RNA, protein, sialic acid and glycogen concentration of the uterus. Vaginal RNA and protein contents were low. An anti-estrogenic action of cannabis extract in female gerbils is suggested.