Top Abstract Purchase Related
Home
>
Node
>
Subnode

Breakage of human cell DNA after exposure to 3-methylcholanthrene-11,12-oxide

Vaught, J.B.; Howard, E.F.; Bresnick, E.

Cancer Research 36(1): 272-275

1976

ISSN/ISBN: 0008-5472
PMID: 174812
Document Number: 103675
Damage to and repair of DNA isolated from human neonatal and fetal skin cells were measured by alkaline sucrose gradient analysis. 3-Methylcholanthrene did not induce single-strand breaks in DNA of the cells in culture, whereas the 11,12-oxide of 3-methylcholanthrene was very effective in this regard. The cis-1,2-dihydroxy, trans-11,12-dihydroxy, and cis-11,12-dihydroxy derivatives of 3-methylcholanthrene exerted little effect. The breaks in DNA caused by 3-methylcholanthrene oxide occurred during a 60-min incubation period and were repaired during the following 60 min. Methylmethane sulfonate also induced breaks in the DNA within 60 min.

Document emailed within 1 workday
Secure & encrypted payments

Deng, X.; Wu, J.; Guo, X.; Han, X.; Ding, X. 2000: Effect of 8-bromo-cyclic AMP on neuron specific enolase, heat shock protein, nitric oxide, nitric oxide synthase and nitric oxide synthase mRNA in human retinoblastoma HXO-Rb44 cells and cell differentiation Chinese Medical Journal 113(3): 198-200
Wraith, M.J.; Watson, W.P.; Eadsforth, C.V.; van Sittert, N.J.; Törnqvist, M.; Wright, A.S. 1988: An immunoassay for monitoring human exposure to ethylene oxide Iarc Scientific Publications 89: 271-274
Malkinson, A.M.; Koski, K.M.; Evans, W.A.; Festing, M.F. 1997: Butylated hydroxytoluene exposure is necessary to induce lung tumors in BALB mice treated with 3-methylcholanthrene Cancer Research 57(14): 2832-2834
Anderson, L.M.; Seetharam, S. 1985: Protection against tumorigenesis by 3-methylcholanthrene in mice by beta-naphthoflavone as a function of inducibility of methylcholanthrene metabolism Cancer Research 45(12 Part 1): 6384-6389
Kano, Y.; Sakamoto, S.; Sakuraya, K.; Kubota, T.; Kasahara, T.; Hida, K.; Suda, K.; Takaku, F. 1983: Effects of nitrous oxide on human cell lines Cancer Research 43(4): 1493-1496
Ho, D.; Gill, K.; Fahl, W.E. 1983: Benz[a]anthracene and 3-methylcholanthrene induction of cytochrome P-450 in C3H/10T1/2 mouse fibroblasts. Modulating role of cytotoxic 3-methylcholanthrene metabolites Molecular Pharmacology 23(1): 198-205
Qureshi, M.A.; Shah, N.J.; Hemmen, C.W.; Thill, M.C.; Kruse, J.A. 2003: Exposure of intensive care unit nurses to nitric oxide and nitrogen dioxide during therapeutic use of inhaled nitric oxide in adults with acute respiratory distress syndrome American Journal of Critical Care: An Official Publication American Association of Critical-Care Nurses 12(2): 147-153
Robbins, C. 2006: Hair breakage during combing. I. Pathways of breakage Journal of Cosmetic Science 57(3): 233-243
Arai, Y.T.; Montalban, C.S. 1993: Comparative studies on chick embryo cell rabies vaccine and human diploid cell vaccine: pre-exposure use and purity of the vaccines Southeast Asian Journal of Tropical Medicine and Public Health 24(4): 747-750
Konur, A.; Krause, S.W.; Rehli, M.; Kreutz, M.; Andreesen, R. 1996: Human monocytes induce a carcinoma cell line to secrete high amounts of nitric oxide Journal of Immunology 157(5): 2109-2115
Jiang, G.; Akers, M.; Jain, M.; Guo, J.; Distler, A.; Swift, R.; Wadhwa, M.-V.S.; Jameel, F.; Patro, S.; Freund, E. 2007: Mechanistic studies of glass vial breakage for frozen formulations. I. Vial breakage caused by crystallizable excipient mannitol PDA Journal of Pharmaceutical Science and Technology 61(6): 441-451
Horwitz, S.B.; Horwitz, M.S. 1973: Effects of camptothecin on the breakage and repair of DNA during the cell cycle Cancer Research 33(11): 2834-2836
Linn, S.C.; Morelli, P.J.; Edry, I.; Cottongim, S.E.; Szabó, C.; Salzman, A.L. 1997: Transcriptional regulation of human inducible nitric oxide synthase gene in an intestinal epithelial cell line American Journal of Physiology 272(6 Pt 1): G1499-G1508
Kamath, Y.K.; Robbins, C. 2011: Hair breakage by combing and brushing--a comment on: T. A. Evans and K. Park, A statistical analysis of hair breakage. II. Repeated grooming experiments, J. Cosmet. Sci., 41, 439-456 (2010) Journal of Cosmetic Science 62(6): 579-585
Gallo R.C. 1985: Evidence for exposure to human t cell leukemia virus iii in uganda before 1973 Science 227(4690): 1036-1038
Kuwert, E.K.; Marcus, I.; Werner, J.; Scheiermann, N.; Höher, P.G.; Thraenhart, O.; Hierholzer, E.; Wiktor, T.J.; Koprowski, H. 1976: Post-exposure use of human diploid cell culture rabies vaccine Developments in Biological Standardization 37: 273-286
Russell-Brown, P.; Piedrahita, C.; Foldesy, R.; Steiner, M.; Townsend, J. 1992: Comparison of condom breakage during human use with performance in laboratory testing Contraception 45(5): 429-437
Gomi, K.; Morimoto, M.; Nomoto, K. 1982: Effects of levamisole on methylcholanthrene-induced tumor. II. Potentiation of cytotoxic T-cell activities Gan to Kagaku Ryoho. Cancer and ChemoTherapy 9(7): 1269-1276
Kakunaga, T. 1975: The role of cell division in the malignant transformation of mouse cells treated with 3-methylcholanthrene Cancer Research 35(7): 1637-1642
Bauer, U. 1981: Human exposure to environmental chemicals - investigations on volatile organic halogenated compounds in water, air, food, and human tissues. IV. Communication: calculation of human exposure to organic halogenated compounds from the environment Zentralblatt für Bakteriologie Mikrobiologie und Hygiene. 1. Abt. Originale B Hygiene 174(6): 556-583