Use of sodium 4-hydroxybutyrate in anesthesia and resuscitation
Laborit, H.; Buchard, F.; Laborit, G.; Kind, A.; Weber, B.
Agressologie Revue Internationale de Physio-Biologie et de Pharmacologie Appliquees Aux Effets de l'Agression 1: 549-560
1960
ISSN/ISBN: 0002-1148 PMID: 13758007 Document Number: 10356
The authors report the first employment which they have made in human anesthesiology and in reanimation of the 4-hydroxybutyrate of Na, of which their group has realized the synthesis and pharmacological study, published at an earlier date. This study refers to 43 general anesthesias and 20 hibernations, viz. 63 patients. In anesthesia. Although of a sufficiently potent narcotic effect at adequate doses, it seems preferable to the authors to utilize it combined to a neuroplegia. The principal characteristics of its action are : - The absence of perturbation of the oxidizing metabolisms, as for the first time, one has been able to realize an anesthetic sleep without diminution of the oxygen consumption. The latter seems to prove a particular mechanism of action and to explain its weak toxicity. - A potent tonicardiac action with a tendency to bradycardia, allowing to make disappear the tachycardia effect of the neuroplegics; the arterial pressure is not influenced; even a light hypertension is sometimes observed. - A bradypnea with increasing amplitude of ventilation. - An action tending to hypothermia and facilitating hibernation. In reanimation. The obvious diminution of the nitrogen catabolism leads the authors to discuss the mechanism of action of the product. They bring up that it allows probably the preferential utilization of the fats without acidosis. That property, the experimental biological study of which is being carried out, seems them to have a considerable importance, because the increase of the nitrogen catabolism has up to now been a practically ineluctable consequence of any organic reaction to aggressions.
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