A pharmacologic model of Huntington's chorea
Dill, R.E.; Dorris, R.L.; Phillips-Thonnard, I.
Journal of Pharmacy and Pharmacology 28(8): 646-648
1976
ISSN/ISBN: 0022-3573 PMID: 11317 Document Number: 103344
The effects of L-dopa, a MAOI(monoamine oxidase inhibitor, pheniprazine) and 3 neuroleptic drugs (haloperidol, trifluoperazine and clozapine, i.p.) on 3-MT(3-methoxytyramine)-induced dyskinesias in rats were studied. There was a close parallel between the drug response of the i.s. 3-MT model of Huntington's chorea and the disease in man. A parallel exists between the drug response of this model and the response of schizophrenic patients to L-dopa, and the response of schizophrenic patients to L-dopa, MAOI and neuroleptics.