Evidence for a particle-associated RNA-directed DNA polymerase in rabbit placental and uterine tissues
Bedigian, H.G.; Fox, R.R.; Meier, H.
Cancer Research 36(12): 4687-4692
1976
ISSN/ISBN: 0008-5472 PMID: 63325 Document Number: 103183
A RNA-directed DNA polymerase associated with particles that band at a density characteristic of type C RNA viruses was found in normal rabbit placental and uterine tissues taken during the early stages of gestation. That the rabbit RNA-directed DNA polymerase is distinct from the known cellular DNA polymerases and similar to the RNA-directed DNA polymerase of mammalian type C RNA viruses is shown by column chromatographic characteristics, template primer preferences, molecular weight determination, and an absolute requirement for the divalent cations.