Effect of polyvinylpyridine-N-oxide on the state of phagocyte-lymphoid elements in aseptic inflammation
Iashchenko, L.V.; Gladkova, N.A.; Gakh, L.M.; Etlis, V.S.; Grobov, L.N.
Farmakologiia i Toksikologiia 39(5): 586-589
1976
ISSN/ISBN: 0014-8318 PMID: 800766 Document Number: 102695
Cytochemical study of NAD-diaphorase and acid phosphatase (mitochondria and lysosomes markers) in the cells of the abdominal cavity exudate with aseptic inflammation and additional action of polyvinylpyridne-N-oxide with molecular weight in the range of from 2000 to 150 000 formed a background for demonstrating the possibility of stabilizing by means of the latter compound of mitochondrial and lysosomal membranes of macrophages, neutrophils and lymphocytes. The most pronounced stabilizing effect is produced by polyvinylpyridine-N-oxide with a molecular weight of 50 000 with its intramuscular introduction in a dose of 100 mg/kg.