Cell surface antigens detected in cell lines established from lymphomatous Papio hamadryas and Macaca arctoides monkeys
Bubeník, J.; Jandlová, T.; Símová, J.; Agrba, V.Z.; Yakoleva, J.A.; Lapin, B.A.; Kokoscha, L.V.; Klepikov, N.N.; Voevodin, V.F.
Neoplasma 23(5): 463-470
1976
ISSN/ISBN: 0028-2685 PMID: 185533 Document Number: 102624
Cell surface antigens associated with bone marrow cell cultures [KMPG-1 and KMMA-2] from leukemic monkeys of the species P. hamadryas and M. arctoides were visualized by means of an indirect immunofluorescence method with sera from leukemic baboons. The same immune serum gave 2 types of immunofluorescence, depending on the origin of the target cells. Fluorescence of the ring-reaction type was seen with P. hamadryas bone marrow cell cultures growing in suspension and containing the baboon herpesvirus, whereas the patchy type of fluorescence was noted with monolayer bone marrow cell cultures from M. arctoides origin, containing type-C oncornavirus but not the herpesvirus particles. Absorption experiments showed that antibodies responsible for the patchy type of immunofluorescence could be absorbed with a disintegrated type-C baboon oncornavirus, and not with baboon lymphoblastoid cell lines containing the herpesvirus nor with human lymphoblastoid cell lines [human Burkitt's lymphoma P3HR-1 lymphoblasts and human Hodgkin's disease CSL-1 lymphoblasts] containing the Epstein-Barr virus.