Effect of atropine upon the cardiovascular system during soman-induced respiratory depression
Lipp, J.A.
Archives Internationales de Pharmacodynamie et de Therapie 220(1): 19-27
1976
ISSN/ISBN: 0003-9780 PMID: 821408 Document Number: 102268
The effects of atropine, doxapram and isoproterenol upon soman-induced respiratory depression were investigated in the monkey. Administration of atropine resulted in an immediate increase in heart rate accompanied by a gradual increase in respiratory rate. The improvement in the EEG pattern coincided with improvement in respiratory function. Administration of either doxapram or isoproterenal during soman-induced apnea failed to significantly alter any of the physiological parameters. Clonazepam was used to control soman-induced seizure activity and convulsions.