The binding of chloramphenicol to serum proteins in patients with chronic renal insufficiency
Grafnetterová, J.; Vodrázka, Z.; Jandová, D.; Schück, O.; Tomásek, R.; Lachmanová, J.
Clinical Nephrology 6(4): 448-450
1976
ISSN/ISBN: 0301-0430 PMID: 975643 Document Number: 101431
The binding (r) of chloramphenicol to serum proteins is significantly lower in patients with chronic renal failure than in normal subjects. Before hemodialysis, the mean r value in patients with chronic renal insufficiency was 0.165 mg/g (+/-0.003) versus 0.188 mg/g (+/-0.004) in healthy individuals. Hemodialysis produced a significant rise in r (to 0.182 mg/g, +/-0.004). Decrease in the serum concentration of albumin in patients with chronic renal insufficiency does not seem to be the sole factor responsible for decreased r.