Chronic and relapsing acute pancreatitis associated with chronic renal insufficiency and analgesic (phenacetin) abuse. Observations in 4 patients
Ammann, R.W.; Bühler, H.; Tuma, J.; Schneider, J.; Siebenmann, R.; Satz, N.
Gastroenterologie Clinique et Biologique 5(5): 509-514
1981
ISSN/ISBN: 0399-8320 PMID: 7250605 Document Number: 176182
Three cases of idiopathic silent calcifying chronic pancreatitis (female patients of ages 48, 56 and 58 yr) and one of relapsing acute pancreatitis of unknown origin (male patient, age 38 yr) were reported. All patients had associated chronic mild renal insufficiency probably secondary to chronic interstitial nephritis and analgesic abuse. Morphological renal changes compatible with analgesic nephropathy were observed by pathological study (twice) or radiologically (once). Renal and pancreatic disease were detected simultaneously in 3 cases. There was no evidence of a primary disease being responsible for both disorders or of renal disease being secondary to pancreatitis and vice versa. Chronic analgesic (phenacetin/paracetamol) abuse may be an unrecognized etiological factor of chronic painless calcifying pancreatitis.