Removal of amantadine hydrochloride by dialysis in patients with renal insufficiency
Ing, T.S.; Mahurkar, S.D.; Dunea, G.; Hayashi, J.A.; Klawans, H.L.; Markey, W.S.
Canadian Medical Association Journal 115(6): 515
1976
ISSN/ISBN: 0008-4409 PMID: 953934 Document Number: 101377
Two patients with Parkinson's disease and renal insufficiency had excessively high concentrations of amantadine hydrochloride in the blood. The amounts of the drug removed by hemodialysis and peritoneal dialysis were small. However, since extrarenal elimination is negligible in such patients, frequently repeated dialysis may be required to remove the drug.