Action of KCN on intact and refractory thrombocytes
Lisovskaia, I.L.; Volkova, R.I.; Pozin, E.I.; Markosian, R.A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 82(8): 940-943
1976
ISSN/ISBN: 0365-9615 PMID: 1026293 Document Number: 101031
The effect of low KCN concentrations (5-10(4) M) on the ADP-induced aggregation of intact and refractory rabbit platelets was studied. KCN did not change the aggregation of the intact platelets, but stimulated that of the refractory platelets. The effect of the inhibitor stimulating the aggregation was not connected with the release of additional amounts of ADP. A different sensitivity of the aggregation capacity of the intact and refractory cells to the partial inhibition of metabolism was discussed in terms of the suggested earlier "calcium" model of autoregulation of platelet aggregation.