Uptake, localization and secretagogic action of some biogenic amines in the submandibular and pancreatic glands of the guinea pig
Alm, P.; Carlsöö, B.; Danielsson, A.; Sehlin, J.
Medical Biology 54(3): 210-216
1976
ISSN/ISBN: 0302-2137 PMID: 1084942 Document Number: 100919
The effects of noradrenaline, 5-hydroxytryptamine (5-HT), 5-hydroxytryptophan (5-HTP), dopamine, L-DOPA and carbamylcholine on the secretion of amylase from guinea pig submandibular gland and pancreas were studied. Carbamylcholine stimulated both pancreatic and salivary gland amylase release, whereas the biogenic amines elicited amylase secretion only from the submandibular gland. L-DOPA and 5-HTP, the precursor amino acids of dopamine and 5-HT, were without effects. In both glands 5-HT and dopamine were accumulated to a greater extent than their precursor amino acids. The uptake of biogenic amines into acinar cells and their effects on amylase secretion are compared and discussed in terms of receptor specificity.