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HLA class II allele frequencies in northern Thais (Kamphaeng Phet)

Maneemaroj, R.; Stephens, H.A.; Chandanayingyong, D.; Longta, K.; Bejrachandra, S.

Journal of the Medical Association of Thailand 80(Suppl): S20-S24

1997

ISSN/ISBN: 0125-2208
PMID: 9347641
Document Number: 1008
The polymorphism of HLA class II genes (HLA-DRB1, -DQA1, -DQB1 and -DPB1) was investigated in 97 normal Northern Thais (NT) from Kamphaeng Phet province using PCR-SSO typing. Allele frequencies (AF) have been determined. DRB1*1202 (17.5%), DRB1*1502 (16.5%), DQA1*0101 (25.8%), DQA1*0102 (21.7%), DQB1*0502 (22.7%), DPB1*0501 (23.2%) and DPB1*1301 (22.7%) showed the highest frequencies in each locus. These results were more similar to those observed in Present-day Thais (PDT) and Central Thais (CT) than Northern Thais from Chiang Mai (CM) and Dai Lue (DL). However, the data presented in this population study should be useful in many fields, such as anthropology, organ transplantation, disease susceptibility and evolutionary genetics.

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